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. 2022 Dec 6;23(23):15412. doi: 10.3390/ijms232315412

Figure 2.

Figure 2

Time course analysis of MeHg-induced ER stress using ERAI-Venus mice. ERAI-Venus mice were exposed to 50 ppm MeHg via drinking water. At the indicated times, the mice were sacrificed, and the brain tissues were analyzed by immunostaining. (a,c) ERAI fluorescence signal in the somatosensory cortex and striatum of ERAI-Venus mice exposed to MeHg for the indicated time. The scale bar represents 50 μm. (b,d) Quantification of ERAI-positive cells shown in (a,c). Data are expressed as the mean ± S.E.M. values (n = 5–6, ** p < 0.01, and *** p < 0.001: significant difference compared with control mice without MeHg exposure (0 weeks) by one-way ANOVA with Dunnett’s post hoc test).