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. 2022 Dec 6;23(23):15412. doi: 10.3390/ijms232315412

Figure 3.

Figure 3

Effect of MeHg exposure on IRE1α-XBP1 axis in the mouse brain. (a,d) Detection of p-IRE1α and HRD1 in the somatosensory cortex (a) or striatum (d) of ERAI-Venus mice exposed to MeHg for the indicated times. Each scale bar represents 50 μm. (b,e) Quantification of p-IRE1α-positive cells in the somatosensory cortex (b) or striatum (e). (c,f) Quantification of HRD1-positive cells in the somatosensory cortex (c) or striatum (f). Data are expressed as the mean ± S.E.M. values (n = 5–6, ** p < 0.01, and *** p < 0.001: significant difference compared with control mice without MeHg exposure (0 weeks) by one-way ANOVA with Dunnett’s post hoc test).