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. 2022 Nov 25;14(23):5025. doi: 10.3390/nu14235025

Figure 1.

Figure 1

Puerariae lobatae Radix (PLR) alleviated pre-eclampsia (PE)-like symptoms in NG-nitro-L-arginine methyl ester (L-NAME)-induced mice. (A) The schematic diagram of the experimental design and procedure. (B) Systolic blood pressure (SBP) of the four groups was measured non-invasively. a indicates p < 0.001 for the Control group versus the PE group on the corresponding day. b indicates p < 0.05, bb indicates p < 0.01, and bbb indicates p < 0.001 for the PE+PLR d9 group versus the PE group on the corresponding day. c indicates p < 0.05, cc indicates p < 0.01, and ccc indicates p < 0.001 for the PE+PLR d18 group versus the PE group on the corresponding day. d indicates p < 0.05 for the Control group versus the PE+PLR d9 group on the corresponding day. e indicates p < 0.05 for the Control group versus the PE+PLR d18 group on the corresponding day. (C) The 24 h proteinuria on GD18. (D) Number of pups per litter. (E) Fetal weight and placental weight. (F) Representative images of H&E-stained midsagittal placental tissue sections used in histomorphological analysis (original magnification, ×25; scale bar, 1 mm). Zones are marked and indicated by labyrinth zone and junctional zone. For (B,D,E), n = 8 for each group. For (C), n = 7 for each group. For (F), n = 6 for each group. Data are expressed as the mean ± SEM. * p < 0.05, ** p < 0.01, *** p < 0.001 (ANOVA test).