TABLE 1.
Summary of BLAST search of clones that were specific for E. coli strain C5 and had significant homologiesa
| Cloneb | Insert size (bp) | Sequence(s) with similarityc | Score | Probability | GenBank accession no. |
|---|---|---|---|---|---|
| SauE15.A1 | 163 | IS629 (N), plasmid pO157, E. coli O157:H7 | 315 | e−84 | AB011549 |
| SauE15.A7 | 190 | iroC (N), ATP cassette transporter (iron-regulated locus), Salmonella enterica serovar Typhi | 157 | e−37 | U6129 |
| SauE15.B2 | 294 | repB (N); replication protein, plasmid pCD1; Yersinia pestis | 123 | e−26 | AF053946 |
| SauE15.B6 | 157 | kps (N), promoter region of polysialic acid gene cluster region 3, E. coli | 242 | e−62 | U05251 |
| SauE15.B9 | 107 | traD (N), F sex factor plasmid, E. coli | 198 | e−50 | M29254 |
| SauE15.B10 | 240 | ORF 34 and 35 (P), 102-kb unstable region, Y. pestis | 69 | e−12 | CAA21357 |
| SauE15.B12 | 479 | unknown protein (P), E. coli ec11 | 102 | e−21 | AF044503 |
| SauE15.C1 | 100 | r6 (N), transposase, pathogenicity island of E. coli CFT073 | 198 | e−49 | AF081285 |
| SauE15.C6 | 119 | IS100 (N), Y. pestis | 228 | e−58 | L19030 |
| SauE15.C7 | 155 | TonB-dependent receptor HI1217 precursor (P), Haemophilus influenzae | 52 | e−7 | P45114 |
| SauE15.C9 | 273 | rhuM (N), pathogenicity island of Salmonella enterica serovar Typhimurium (SPI3) | 311 | e−83 | AF106566 |
| SauE15.C11 | 77 | orfE (N); promoter-distal region of the tra operon, plasmid R100; S. flexneri | 129 | e−29 | X55815 |
| SauE15.D4 | 153 | IS100 (N), Y. pestis | 287 | e−76 | L19030 |
| SauE15.D8 | 347 | r3 (N), beta-cystathionase, pathogenicity island of E. coli CFT073 | 615 | e−174 | AF081286 |
| SauE15.E4 | 281 | senB (N), enterotoxin, E. coli | 541 | e−152 | Z54195 |
| SauE15.E11 | 314 | traJ, Y (N), plasmid R1–19, E. coli | 523 | e−147 | M19710 |
| SauE15.F3 | 422 | chuA (P), heme utilization gene, E. coli O157:H7 | 98 | e−20 | U67920 |
| SauE15.F9 | 137 | Thioesterase (P), Bacillus sp. | 48 | e−6 | AB016427 |
| SauE15.F10 | 210 | r3 (N), beta-cystathionase, pathogenicity island of E. coli CFT073 | 408 | e−112 | AF081286 |
| SauE15.G3 | 206 | traG (N), plasmid R100, S. flexneri | 165 | e−39 | U01159 |
| SauE15.G6 | 328 | IS100 (N), Y. pestis | 480 | e−134 | L19030 |
| SauE15.H5 | 200 | HMWP1 protein (P), Yersinia enterocolitica | 80 | e−15 | CAA73127 |
| SauE15.H7 | 150 | Oxydoreductase (P), Thermotoga maritima | 160 | e−11 | AE001762 |
| SauE15.H10 | 141 | traT (N), plasmid R100, E. coli | 280 | e−74 | J01769 |
| SauE15.H11 | 160 | Hemoglobin protease (P), E. coli EB1 | 50 | e−6 | CAA11507 |
| SauE15.I3 | 176 | asst (N), arylsulfate sulfotransferase, Klebsiella sp. | 341 | e−92 | U32616 |
| SauE15.I11 | 162 | chuA (N), heme utilization gene, E. coli O157:H7 | 305 | e−82 | U67920 |
| SauE15.J7 | 118 | iroB (N), glucosyl transferase homolog, Salmonella serovar Typhi | 74 | e−12 | U62129 |
| SauE15.J9 | 96 | IS100 (N), Y. pestis | 174 | e−42 | L19030 |
| SauE15.M4 | 193 | r3 and malX (N), pathogenicity island of E. coli CFT073 | 383 | e−104 | AF081286 |
| SauE15.M8 | 149 | Delta-(l-α-aminoadipyl)-l-cyteinyl-d-valine synthetase (P), Penicillium sp. | 65 | e−11 | P26046 |
| SauE15.M12 | 119 | senB (N), enterotoxin of enteroinvasive E. coli | 228 | e−58 | Z54195 |
| SauE15.N7 | 188 | Plasmid pColBM-C1139 (N), E. coli | 208 | e−52 | M35683 |
| SauE4.A2 | 321 | ORF 36 (N), 102-kb unstable region, Y. pestis | 135 | e−30 | AL031866 |
| SauE4.A5 | 249 | r3 (N), beta-cystathionase, pathogenicity island of E. coli CTF073 | 355 | e−96 | AF081286 |
| SauE4.B4 | 360 | IS200 (N), E. coli | 523 | e−147 | L25845 |
| SauE4.C7 | 275 | Hippurate hydrolase (P), Campylobacter jejuni | 54 | e−7 | P45493 |
| SauE4.C11 | 255 | Pristinamycine I synthase (P), Streptomyces spp. | 51 | e−6 | CAA67248 |
| SauE4.D3 | 239 | hlyB (N), hemolysine, E. coli | 474 | e−132 | M81823 |
| SauE4.E3 | 263 | shuX genes (N), heme utilization genes, Shigella dysenteriae | 387 | e−106 | U64516 |
| SauE4.E11 | 242 | IS66 (N), E. coli | 329 | e−88 | AF119170 |
| SauE4.F8 | 188 | sorC genes (N), sor operon for l-sorbose utilization, Klebsiella pneumoniae | 139 | e−31 | X66059 |
| SauE4.F9 | 439 | YfkN (P), Bacillus subtilis | 57 | e−8 | BAA23404 |
| SauE4.F12 | 324 | kpsM (N), polysialic acid gene cluster region 3, E. coli K1 | 642 | 0 | M57382 |
| SauE4.H2 | 85 | sorM (N), sor operon for l-sorbose utilization, K. pneumoniae | 105 | e−22 | X66059 |
| SauE4.I2 | 431 | yihA (N), plasmid R100, S. flexneri | 829 | 0 | AP000342 |
| TspE4.A5 | 271 | pap and prsK (N), P-pili protein, E. coli | 498 | e−139 | X61239 |
| TspE4.A8 | 216 | ORF 17 kD of prs pili operon (N), cytoplasmic protein, E. coli | 387 | e−106 | X61238 |
| TspE4.A9 | 179 | kpsT (N), polysialic acid gene cluster region 3, E. coli K1 | 347 | e−94 | M57381 |
| TspE4.A10 | 212 | HecB (P), putative hemolysin activator transporter, Erwinia chrysanthemi | 73 | e−13 | AAC31980 |
| TspE4.B1 | 229 | r1 (N), pathogenicity island of E. coli CFT073 | 430 | e−119 | AF081286 |
| TspE4.B5 | 215 | Sensory transduction histidine kinase (P), Synechocystis sp. | 52 | e−7 | BAA18223 |
| TspE4.B9 | 319 | senB (N), enterotoxin of enteroinvasive E. coli | 617 | e−175 | Z54195 |
| TspE4.B12 | 430 | IS100 (N), Y. pestis | 698 | 0 | L19030 |
| TspE4.C10 | 267 | Intergenic K42 capsule cluster (N), E. coli | 466 | e−129 | AF118251 |
| TspE4.D2 | 232 | waaL (N), lipid A core-to-surface polymer ligase, E. coli | 404 | e−111 | AF019746 |
| TspE4.D4 | 245 | ORF 169 (N), plasmid F, E. coli | 456 | e−126 | X17539 |
| TspE4.D10 | 222 | cnf1 (N), cytotoxic necrotizing factor, E. coli | 440 | e−122 | X70670 |
| TspE4.D11 | 217 | hlyB (N), hemolysin, E. coli | 422 | e−117 | M81823 |
| TspE4.E3 | 298 | hlyD (N), hemolysin, E. coli | 553 | e−156 | M10133 |
| TspE4.E4 | 267 | ORF 95 (N), plasmid F, E. coli | 482 | e−134 | X17539 |
| TspE4.E6 | 190 | l-sorbose P reductase (P), K. pneumoniae | 112 | e−25 | P37084 |
| TspE4.E8 | 285 | hlyB (N), hemolysin, E. coli | 541 | e−152 | M81823 |
| TspE4.G7 | 238 | tra (N), plasmid F, E. coli | 448 | e−124 | X61575 |
| TspE4.G8 | 323 | Transmembrane protein (P), E. coli | 82 | e−15 | AAA92620 |
| TspE4.H1 | 283 | Arginine deiminase (P), Pseudomonas aeruginosa | 63 | e−10 | P13981 |
| TspE4.H9 | 179 | traT (N), plasmid R100, E. coli | 353 | e−96 | J01769 |
| TspE4.H10 | 223 | prf and papI (N), adhesin regulatory gene, E. coli | 418 | e−115 | X76613 |
| TspE4.H11 | 279 | ORF 9 (N), plasmid F, E. coli | 456 | e−127 | X17539 |
| TspE4.I10 | 269 | neuC (N), capsule gene cluster, E. coli | 492 | e−137 | M84026 |
| TspE4.J1 | 327 | yhtA (N), plasmid R100, E. coli | 521 | e−146 | AP000342 |
| TspE4.J6 | 221 | chuA (N), heme utilization gene, E. coli O157:H7 | 375 | e−102 | U67920 |
| TspE4.K3 | 180 | iss (N), serum survival, E. coli | 270 | e−70 | AF042279 |
| TspE4.K8 | 184 | IS100 (N), E. coli | 190 | e−47 | L19030 |
| prf and papB (N), E. coli | 143 | e−32 | X76613 | ||
| TspE15.A1 | 332 | Na+ H+ antiporter (P), H. influenzae | 96 | e−20 | Q57007 |
| TspE15.C1 | 299 | hra (N), heat-resistant agglutinin, E. coli 99 | 537 | e−151 | U07174 |
| TspE15.C3 | 386 | hcp (N), E. coli | 81 | e−14 | AF044503 |
| TspE15.D7 | 239 | Protein STBA (P), plasmid NR1, E. coli | 87 | e−17 | P11904 |
| TspE15.D9 | 230 | chuA (P), heme utilization gene, E. coli O157:H7 | 89 | e−18 | AAC44857 |
| TspE15.E7 | 360 | kpsS (N), capsule gene cluster region 1, E. coli K5 | 531 | e−149 | X74567 |
| TspE15.G12 | 287 | Putative amino transferase (P), B. subtilis | 72 | e−12 | Q08432 |
| TspE15.H2 | 258 | Pyruvate formate lyase-activating enzyme (P), Streptococcus mutans | 51 | e−6 | AAB89799 |
| TspE15.H5 | 310 | cnf1 (N), cytotoxic necrotizing factor, E. coli | 601 | e−170 | U42629 |
| TspE15.H9 | 273 | Major fimbrial subunit of F17-like fimbriae (P), E. coli | 48 | e−5 | I41206 |
| TspE15.I2 | 112 | prs and papE (N), P-pili protein, E. coli | 222 | e−57 | X62158 |
Only homologies with at least probability of e−5 were retained. Homologies to bacteriophages (n = 21) are not shown.
Clones are designated by the name of the enzyme (Sau or Tsp), followed by the name of the strain used for the subtraction (E4 or E15) and a code composed of a letter and a number.
The name of the gene sequence is given (with similarity type in parentheses), followed by the product or function that is encoded by the gene and/or the gene's location, as well as the organism name. N, similarity at the nucleotide level; P, similarity at the protein level; ORF, open reading frame.