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Potential criteria for the choice of future first-line treatment.
| Anti-Angiogenics-Based | Anti-CTLA-4-Based | ||
|---|---|---|---|
| Bevacizumab-Based | TKIs-Based | ||
| Strong criteria of choice | Pre-existing untreated auto-immune disorder (psoriasis…) | Severe vascular comorbidities Significant Portal Hypertension |
|
| Criteria of choice subject to interpretation | Better toxicity profile | Non-severe vascular comorbidities Equilibrated arterial hypertension |
|
| Low-risk auto-immune disorder (diabetes, thyroid disorder…) | |||
