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. 2022 Dec 6;17:5947–5990. doi: 10.2147/IJN.S382796

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© 2022 Mo et al.

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(A) Phases of wound healing. Timeline depicting the sequential yet overlapping phases of wound healing namely, hemostasis (red), inflammation (yellow), keratinocyte proliferation, angiogenesis (green) and tissue remodeling (brown). (B) Contribution of hematopoietic cells to wound healing. Reprinted from Thromb. Res. 179. pneja A, Kapoor S, Stavrou EX. Contribution of platelets, the coagulation and fibrinolytic systems to cutaneous wound healing. 179:56–63. Copyright 2019, with permission from Elsevier.⁶⁴

Abbreviations: CXCL4, CXC chemokine ligand 4; ECM, extracellular matrix; EGF, epidermal growth factor; FGF, fibroblast growth factor; IL, interleukin; MMP, matrix metalloproteinase; PDGF, platelet derived growth factor; PF4, platelet factor 4; TGF-β, transforming growth factor-β; TNF-α, tumor necrosis factor-α; uPAR, urokinase plasminogen activator receptor; VEGF, vascular endothelial growth factor.