Table 2.
The relationship between the SNPs in inflammation-related genes with the susceptibility of CCA. Various studies investigated SNPs in inflammation-related genes related to the susceptibility of CCA.
| Gene | SNP | Factor | Method | Sample | Case (%) | Control (%) | OR (95% CI) | p Value | Susceptibility | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| PTGS2 | rs689466 | C | TaqMan | Blood | 163 (22) | 252 (17) | 1.36 (1.10–1.69) | 0.005 | Increase | Chaiteerakij et al., 2015 [26] |
| rs2143417 | T | TaqMan | Blood | 148 (20) | 207 (14) | 1.52 (1.21–1.91) | 0.0003 | Increase | ||
| IL6 | rs1800795 | GC | PCR-RFLP | Blood | 45 (40.9) | 67 (33.5) | 2.35 (1.31–4.21) | Increase | Surapaitoon et al., 2017 [41] | |
| GC | PCR-RFLP | Blood | 45 (40.9) | 59 (29.5) | 2.95 (1.64–5.31) | Increase | ||||
| C | PCR-RFLP | Blood | 111 (50.5) | 93 (23.3) | 3.36 (2.32–4.85) | Increase | ||||
| IFNG | rs2430561 | AA | PCR-RFLP | Blood | 54 (49.1) | 65 (32.5) | 2.20 (1.13–4.20) | Increase | ||
| TNF | rs1800629 | A | PCR-RFLP | Blood | 173 (78.6) | 284 (71.0) | 1.50 (1.00–2.26) | Increase | ||
| A | PCR-RFLP | Blood | 173 (78.6) | 278 (69.5) | 1.61 (1.08–2.43) | Increase |
CI, confidence interval; PTGS2, Cyclooxygenase-2; IL6, Interleukin 6; IFNG, Interferon gamma; TNF, Tumor necrosis factor; OR, odds ratio; PCR-RFLP, Polymerase chain reaction–restriction fragment length polymorphism.