Table 3.
The relationship between SNPs in DNA repair genes and cellular protection against toxin genes with the susceptibility of CCA. Various studies investigated the SNPs of DNA repair genes and cellular protection against toxin genes related to the susceptibility of CCA. NAT2*6B, 590G > A (rs1799930); NAT2*7A, 857G > A (rs1799931); NAT1*11 and NAT2*13.
| Gene | SNP | Factor | Method | Sample | Case (%) | Control (%) | OR (95% CI) | p Value | Susceptibility | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| ERCC1 | rs3212986(ECCA) | AC + AA | PCR-RFLP | Blood | 68 (53.5) | 59 (40.7) | 1.68 (1.04–2.72) | 0.03 | Increase | Sun et al., 2018 [40] |
| MTHFR | rs1801131 | CC | PCR-HRM | Tissues | 62 (35.4) | 72 (20.6) | 2.00 (1.14–3.48) | Increase | Songserm et al., 2011 [39] | |
| NAT1 | * 11 | PCR-RFLP | Blood | 1 (0.2) | 11 (2.4) | 0.10 (0.00–0.58) | 0.005 | Decrease | Prawan et al., 2005 [38] | |
| NAT2 | * 13 | PCR-RFLP | Blood | 8 (1.9) | 24 (5.2) | 0.35 (0.16–0.77) | 0.008 | Decrease | ||
| rs1799930 | * 6B | PCR-RFLP | Blood | 6 (1.4) | 22 (4.7) | 0.28 (0.12–0.69) | 0.004 | Decrease | ||
| rs1799931 | * 7A | PCR-RFLP | Blood | 9 (2.1) | 28 (6.0) | 0.33 (0.16–0.70) | 0.003 | Decrease | ||
| MUTYH | rs3219476 | TG | PCR-RFLP | Blood | 20 (30.9) | 58 (58.0) | 0.36 (0.17–0.76) | 0.006 | Decrease | You et al., 2013 [42] |
| rs3219472 | AA | PCR-RFLP | Blood | 12 (20.3) | 7 (7.0) | 2.82 (0.99–8.00) | 0.047 | Increase | ||
| ABCC2 | rs3740066 | T | TaqMan | Blood | 47 (39.2) | 38 (26.0) | 1.83 (1.09–3.08) | 0.022 | Increase | Höblinger et al., 2009 [28] |