Table 4.
SNPs in other genes associated with susceptibility to CCA. Various studies investigated the gene SNPs related to the susceptibility of CCA.
| Gene | SNP | Factor | Method | Sample | Case (%) | Control (%) | OR (95% CI) | p Value | Susceptibility | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| SERPINA1 | rs28929474 (Z) | T | TaqMan | Blood | 15 (4.0) | 12 (2.0) | 2.46 (1.14–5.32) | 0.036 | Increase | Mihalache et al., 2015 [37] |
| GSTO1 | rs4925 | D140 | PCR | Tissues | 18 (30.0) | 4 (6.7) | 8.50 (2.07–37.85) | <0.05 | Increase | Marahatta et al., 2005 |
| MST1 | rs3197999 | GG | TaqMan | Blood | 115 (52.0) | 194 (55.0) | 1.97 (1.09–3.36) | 0.023 | Increase | Krawczyk et al., 2013 [32] |
| AA (ECCA) | TaqMan | Blood | 22 (12.0) | 24 (6.0) | 2.04 (1.09–3.84) | 0.024 | Increase | |||
| HOTAIR | rs4759314 | GG | PCR-RFLP | Blood | 7 (5.7) | 1 (0.6) | 12.31 (1.48–101.87) | 0.005 | Increase | Lampropoulou et al., 2021 [33] |
| AG | PCR-RFLP | Blood | 32 (26.3) | 18 (10.9) | 3.13 (1.65–5.91) | 0.0004 | Increase | |||
| KLRK1 | rs11053781 | G/A | TaqMan | Blood | 32 (66.0) | 184 (50.0) | 1.95 (1.23–3.07) | 0.0038 | Increase | Melum et al., 2007 [34] |
| rs2617167 | A/G | TaqMan | Blood | 19 (39.0) | 85 (23.0) | 2.20 (1.40–3.44) | 0.00046 | Increase | ||
| GAB1 | rs3805246 | AA + AG VS GG | TaqMan | Tissues | 154 (68.4) | 71 (31.6) | 2.15 (1.28–3.71) | 0.016 | Increase | Lingqin et al., 2014 [35] |
| AA VS (AG + GG) | TaqMan | Tissues | 35 (15.5) | 190 (84.5) | 1.98 (1.21–2.84) | 0.012 | Increase | |||
| EGFR | rs2017000 | AA | TaqMan | Blood | 26 (11.6) | 1.92 (1.14–2.59) | 0.002 | Increase | Lingqin et al., 2015 [70] | |
| APOBEC3B | rs2267401 | TG | Taqman | Blood | *** | *** | 0.51 (0.36–0.72) | 0.00016 | Decrease | Liu et al., 2022 [45] |
| TG + GG | Taqman | Blood | *** | *** | 0.69 (0.51–0.94) | 0.0189 | Decrease | |||
| APOBEC3A | rs12157810 | CC | Taqman | Blood | *** | *** | 0.44 (0.33–0.60) | <0.001 | Decrease | |
| AC + CC | Taqman | Blood | *** | *** | 0.80 (0.66–0.97) | 0.025 | Decrease |
*** No data shown in the original publication. APOBEC3, Apolipoprotein B mRNA editing enzyme-catalytic polypeptide-like 3; EGFR, Epidermal growth factor receptor; GAB1, GRB2 associated binding protein 1; GSTO1, Glutathione S-transferase omega 1; HOTAIR, lncRNA HOX transcript antisense RNA; MST1, Macrophage stimulating 1; KLRK1, Killer cell lectin-like receptor K1; OR, Odds ratio; SERPINA1, Serpin family A member 1.