Table 5.
Relationship between SNPs and clinical prognosis of cholangiocarcinoma. Various studies investigated the association between SNPs and oncological prognosis of cholangiocarcinoma.
| Gene | SNP | Factor | Method | Samples | Case (%) | Control (%) | p Value | Prognosis (OS) | Reference |
|---|---|---|---|---|---|---|---|---|---|
| GNB3 | rs5443 | CC VS (CT + TT) | PCR | Blood | 17 (42.5) | 23 (57.5) | <0.05 | Improved | Fingas et al., 2009 [27] |
| NFE2L2 | rs6726395 | GG VS (AA/GG) | TaqMan | Blood | 34 (38.6) | 54 (61.4) | 0.006 | Improved | Khunluck et al., 2014 [30] |
| GALNT14 | rs9679162 | TT VS (TG + GG) | Sanger sequencing | Tissues | 35 (31.3) | 77 (38.7) | 0.023 | Reduced | Liang et al., 2017 [95] |
| EGFR | rs2017000 | AA VS (GG + GA) | TaqMan | Blood | 21 (10.2) | 105 (88.8) | 0.021 | Reduced | Lingqin et al., 2015 [70] |
| XRCC1 | rs25487 | Arg/Arg VS(Arg/Gln + Gln/Gln) | TaqMan | Blood | 17 (51.5) | 16 (48.5) | 0.013 | Reduced | Pacetti et al., [98] |
| EZH2 | rs887569 | TT VS (CC + CT) | TaqMan | Blood | *** | *** | 0.036 | Improved | Paolicchi et al., 2013 [99] |
| GNAS1 | rs7121 | TT VS (CT + CC) | PCR | Tissues | 7 (14.0) | 40 (85.1) | <0.008 | Reduced | Schmitz et al., 2007 [100] |
| CXCR1 | rs2234671 | CC VS CG | PCR-RFLP | Tissues | 92 (83.6) | 18 (16.4) | 0.002 | Improved | Lurje et al. [101] |
*** No data shown in the original. CXCR1, C-X-C motif chemokine receptor 1; EGFR, Epidermal growth factor receptor; EZH2, Enhancer of zeste 2 polycomb repressive complex 2 subunit; GALNT14, Polypeptid N-acetylgalactosaminyltransferase 14; GNB3, G protein subunit beta 3; NFE2L2, NFE2 like bZIP transcription factor 2; OS, overall survival; RFC1, Replication factor C subunit 1; XRCC1, X-ray cross complementation protein 1.