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. 2022 Nov 30;14(23):5925. doi: 10.3390/cancers14235925

Figure 3.

Figure 3

Effects of abemaciclib in association with cisplatin and pemetrexed on cell death in MPM cell lines. (A) MSTO-211H cells were treated with abemaciclib (0.5 µM), cisplatin (0.3 µM), and pemetrexed (0.02 µM), or with the simultaneous combination of abemaciclib and chemotherapy for 72 h. (B) H28, and (C) ZS-LP cells were exposed to the above-described treatments, using abemaciclib 1 µM, cisplatin 1 µM, and pemetrexed 0.05 µM. The percentage of dead cells stained with Hoechst 33,342 and Propidium Iodide is shown. Data are expressed as a percentage of cell death and are the medians of three separate experiments. Comparison among groups was made by using analysis of variance (one-way ANOVA), followed by Bonferroni’s post-test. * p < 0.05, ** p < 0.01, **** p < 0.0001 vs. control cells; §§ p < 0.01, vs. cisplatin + pemetrexed-treated cells; ## p < 0.01, #### p < 0.0001 vs. abemaciclib-treated cells.