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Schematic illustration of the mechanism of interference with the process of cell photoaging. 3D-circ-sEVs were purified from condition medium of circ_0011129-hADSCs in 3D bioreactor culture. Then, HDF cells were co-culture with 3D-circ-sEVs before or during successive UVA irradiation. Ultimately, circ_0011129 were accumulated in cytoplasm, adsorbing miR-6732-5p to inhibit its binding to target RNA. These effects contribute to interfere with the process of cell photoaging.
