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. 2022 Dec 6;11(23):3940. doi: 10.3390/cells11233940

Figure 1.

Figure 1

Human cells express three isoforms of Lonp1. (A). Diagram depicting the location of mitochondrial targeting sequence (MTS), of the nuclear localization signal (NLS), and of the N, AAA+ and P domains of three isoforms of human Lonp1. The length of the three isoforms is indicated. (B). Histogram showing the percentage of Lonp1 isoform-1 (ISO1), Lonp1 isoform-2 (ISO2), and Lonp1 isoform-3 (ISO3) mRNA expression in primary cells (DPSC, dental pulp stem cell; Fibroblasts; HMC3, human microglial cell; Lymphocyte) and cancer cell lines (A375, melanoma; A549, lung cancer; Hela, human cervix epitheloid carcinoma; HepG2, hepatocellular carcinoma; SW480, non-metastatic colon adenocarcinoma; SW620, metastatic colon adenocarcinoma) of different origins. Data represent the mean ± SD. (C–E). Relative expression levels of Lonp1 ISO1, ISO2, and ISO3 mRNA in the indicated primary solid tumours (T) and the normal (N) counterparts, as obtained from TGCA Splicing Variant database (TSVdb). Rectum: rectum adenocarcinoma; Colon: colon adenocarcinoma; Lung: lung adenocarcinoma; Cervical: cervical squamous cell carcinoma and endocervical carcinoma; Bladder: bladder urothelial carcinoma; Prostate: prostate adenocarcinoma; Breast: breast invasive carcinoma; Head and neck: head and neck squamous cell carcinoma; Renal: renal clear cell carcinoma. Data are in log scale; mean, 24 and 75 percentile, max and min values are shown. Data for ISO3 are in linear scale and expressed as mean ± SD * = p < 0.05; ** = p < 0.01; *** = p < 0.0001.