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. 2022 Nov 27;23(23):14840. doi: 10.3390/ijms232314840

Table 1.

SBs mononuclear metal complexes with antimicrobial and antiproliferative activities.

Structure Compound Antimicrobial Activity
(MIC or IZD)		 IC50 Ref
graphic file with name ijms-23-14840-i001.jpg [CuL]Cl2 (1) MIC = 5.6 µM (S. aureus)
MIC = 5.8 µM (B. subtilis)
MIC = 5.4 µM (E. coli)
MIC = 6.2 µM (K. pneumoniae)
MIC = 5.8 µM (S. typhi)
MIC = 5.8 µM (A. niger)
MIC = 5.6 µM (F. solani)
MIC = 5.2 µM (A. flavus)
MIC = 6.4 µM (R. bataticola)
MIC = 6.2 µM (C. albicans)		 IC50 = 14 ± 0.8 µM (HeLa)
IC50 = 16 ± 1.0 µM (MCF-7)
IC50 = 16 ± 1.0 µM (Hep-2)
IC50 = 86 ± 1.0 µM (NHDF)		 Rajakkani et al., 2021 [60]
graphic file with name ijms-23-14840-i002.jpg HNPPd (2) MIC = 3.25 µM; IZD = 28 ± 0.13 mm (S. marcescens)
MIC = 3.75 µM; IZD = 22.5 ± 0.09 mm (E. coli)
MIC = 3.00 µM; IZD = 38.5 ± 0.12 mm (M. luteus)
IZD = 19 ± 0.09 mm
(A. flavus)
IZD = 35.0 ± 0.08 mm
(G. candidum)
IZD = 22.5 ± 0.14 mm
(F. oxysporum)		 IC50 = 6.75 ± 0.08 (HCT-116)
IC50 = 17.85 ± 0.10 (MCF-7)
IC50 = 13.10 ± 0.15 (HepG-2)		 Abu-Dief et al., 2021 [61]
graphic file with name ijms-23-14840-i003.jpg ZnL2 (3) IZD = 13 mm
(E. coli PTCC1394)
IZD = 15 mm
(P. aeruginosa PTCC1074)
IZD = 29 mm
(S. aureus PTCC1431)
IZD = 26 mm
(B. cereus PTCC1015)		 - Kargar et al., 2021 [62]
graphic file with name ijms-23-14840-i004.jpg NiL3 (4) IZD = 13 mm
(E. coli PTCC1394)
IZD = 15 mm
(P. aeruginosa PTCC1074)
IZD = 29 mm
(S. aureus PTCC1431)
IZD = 26 mm
(B. cereus PTCC1015)		 - Kargar et al., 2021 [62]
graphic file with name ijms-23-14840-i005.jpg CuL3 (5) IZD = 16 mm
(E. coli PTCC1394)
IZD = 14 mm
(P. aeruginosa PTCC1074)
IZD = 23 mm
(S. aureus PTCC1431)
IZD = 26 mm
(B. cereus PTCC1015)		 - Kargar et al., 2021 [62]
graphic file with name ijms-23-14840-i006.jpg NilUns (6) IZD = 15 mm
(E. coli PTCC1394)
IZD = 14 mm
(P. aeruginosa PTCC1074)
IZD = 25 mm
(S. aureus PTCC1431)
IZD = 21 mm
(B. cereus PTCC1015)		 - Kargar et al., 2021 [63]
graphic file with name ijms-23-14840-i007.jpg Z2Zn (7) IZD = 15 mm
(M. luteus ATCC 934)
IZD = 21 mm
(S. aureus ATCC 29213)		 IC50 = 25.2 µg/mL (MCF-7)
IC50 = 81.2 µg/mL (A549)
IC50 = 68.7 µg/mL (HDF)		 Al-Shboul et al., 2022 [64]
graphic file with name ijms-23-14840-i008.jpg Z3Zn (8) IZD = 25 mm
(M. luteus ATCC 934)
IZD = 18 mm
(S. aureus ATCC 29213)		 IC50 = 17.7 µg/mL (MCF-7)
IC50 = 199.4 µg/mL (A549)
IC50 = 27.6 µg/mL (HDF)		 Al-Shboul et al., 2022 [64]
graphic file with name ijms-23-14840-i009.jpg Z4Zn (9) IZD = 15 mm
(M. luteus ATCC 934)
IZD = 25 mm
(S. aureus ATCC 29213)		 IC50 = 14.1 µg/mL (MCF-7)
IC50 = 25.2 µg/mL (A549)
IC50 = 28.3 µg/mL (HDF)		 Al-Shboul et al., 2022 [64]
graphic file with name ijms-23-14840-i010.jpg Z1Cu (10) IZD = 10 mm
(E. coli ATCC25922)		 IC50 = 10.4 µg/mL (MCF-7)
IC50 = 43.7 µg/mL (A549)
IC50 = 8.5 µg/mL (HDF)		 Al-Shboul et al., 2022 [64]
graphic file with name ijms-23-14840-i011.jpg Z3Cu (11) IZD = 20 mm
(E. coli ATCC25922)		 IC50 = 172.0 µg/mL (MCF-7)
IC50 = 130.0 µg/mL (A549)
IC50 = 92.0 µg/mL (HDF)		 Al-Shboul et al., 2022 [64]
graphic file with name ijms-23-14840-i012.jpg Z2Cu (12) - IC50 = 1.9 µg/mL (MCF-7)
IC50 = 4.0 µg/mL (A549)
IC50 = 1.5 µg/mL (HDF)		 Al-Shboul et al., 2022 [64]
graphic file with name ijms-23-14840-i013.jpg Ni(L2) (13) MIC = 256 µg/mL
(P. aeruginosa 15)
MIC = 50.8→16 μg/mL
(gentamicin S. aureus)
MIC = 32→25.4 μg/mL
(gentamicin E. coli)
MIC = 203.2→128 μg/mL
(amikacin E. coli)		 IC50 = 1.076 ± 0.04039 μg/mL after 72 h
(L. amazonensis)		 Maia et al., 2022 [66]
graphic file with name ijms-23-14840-i014.jpg Cd(H2L) (14) IZD = 11 mm
(P. aeruginosa ATCC 27853, 200 μg/disk)
IZD = 11 mm
(E. faecalis ATCC 23212, 200 μg/disk)
IZD = 11 mm
(S. epidermidis ATCC 34384, 200 μg/disk)		 - Tyula et al., 2023 [67]
graphic file with name ijms-23-14840-i015.jpg Hg(H2L) (15) IZD = 13 mm (P. aeruginosa ATCC 27853, 200 μg/disk)
IZD = 20 mm (E. faecalis ATCC 23212, 200 μg/disk)
IZD = 17 mm (S. epidermidis ATCC 34384, 200 μg/disk)		 - Tyula et al., 2023 [67]
graphic file with name ijms-23-14840-i016.jpg [Zn(HMHC)2]H2O (16) IZD = 23 mm (B. subtilis)
IZD = 23 mm (K. pneumoniae)
IZD = 15 mm (C. albicans)
IZD = 17 mm (A. niger)
Percentage inhibition = 92.2% (Protein denaturation)		 - Saritha et al., 2021 [68]
graphic file with name ijms-23-14840-i017.jpg 17 - IC50 = 1.6 ± 0.1 µM (MCF-7)
IC50 = 9.6 ± 0.1 µM (A549)		 Gowdhami et al., 2022 [72]
graphic file with name ijms-23-14840-i018.jpg 18 - IC50 = 2.9 ± 0.2 µM (MCF-7)
IC50 = 9.1 ± 0.1 µM (A549)		 Gowdhami et al., 2022 [72]
graphic file with name ijms-23-14840-i019.jpg [PdLCl]·H2O (19) - IC50 = 3.4 × 10–6 μg/mL (EAC) Hassona et al., 2022 [73]