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Micronuclei frequency in DSB repair-proficient and -deficient mESCs. (A) Induction of micronuclei (in % of micronuclei among bi-nucleated cells) as a measure of genetic damage in repair-proficient cells in response to increasing doses of IR. Dots and error bars represent median and 95% CI values, respectively. (B) MN frequency in wt, Lig4−/− and Xrcc5−/− cells in response to IR (0.2 Gy).
