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. 2022 Dec 3;23(23):15264. doi: 10.3390/ijms232315264

Table 3.

The amino acidic position within the SARS-Cov-2 spike glycoprotein; the relative amino acids for BA.5 and BQ.1 are reported. DiscoTope scores for both variants are compared. Amino acids that have lost their potential to be considered probable B-cell epitopes are highlighted in red font and labeled with *.

BA5 Amino Acidic
Position
BQ.1 BQ.1 DiscoTope Score BA5 DiscoTope Score
SER 438 SER −3.733 * −2.003
LYS 439 THR 0.220 1.904
VAL 440 VAL 3.112 4.307
GLY 441 GLY 2.203 3.670
GLY 442 GLY 0.553 2.047
ASN 443 ASN −3.125 −1.276
TYR 444 TYR −1.383 0.031
ASN 445 ASN −2.964 −1.719
LEU 487 LEU −4.250 * −3.559
GLN 488 GLN −4.265 * −3.436
SER 489 SER −3.458 −2.349
TYR 490 TYR −4.915 * −3.658
GLY 491 GLY −0.377 0.794
PHE 492 PHE −3.202 −1.742
ARG 493 ARG 0.628 2.089
PRO 494 PRO 1.352 2.664
THR 495 THR 2.953 3.742
TYR 496 TYR −0.290 0.704
GLY 497 GLY 1.939 2.529
VAL 498 VAL −1.746 −0.966
GLY 499 GLY −2.855 −2.103
HIS 500 HIS −2.180 −1.223
GLN 501 GLN −3.523 −2.327