TABLE 1.

Pulmonary clearance of P. aeruginosa in CFTR^m1Unc−/− mice, CFTR^+/+ littermates, and CFTR^m1Unc−/−(FABP-hCFTR) bitransgenic mice with corrected intestinal defect^a

Genotype	Body wt (g)	% Bacterial survival
CFTR+/+	21.0 ± 1.4	0.17 ± 0.03
CFTRm1Unc−/−	6.5–20.7	0.12–122
CFTRm1Unc−/−(FABP-hCFTR)	22.4 ± 2.5	0.10 ± 0.08

^aPulmonary clearance (n = 18) was determined 18 h following exposure to P. aeruginosa aerosols. Bacterial survival at 18 h upon exposure to aerosols was expressed as percentage of the initial bacterial deposition (3 × 10⁶ CFU per lung) determined in animals sacrificed immediately upon exposure.