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. 2022 Nov 25;12(23):4181. doi: 10.3390/nano12234181

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Effect of [¹⁷⁷Lu]Lu−iFAP/iPSMA treatment on HCT116 colorectal cancer xenograft tumors in nu/nu mice. Note a significant decrease in the relative tumor volume in mice treated with the nanoparticles compared to the control group. (b) Representative light micrographs (magnification of 400×) of immunohistochemical staining (dark brown color) for cell proliferation markers Ki67 and pEGFR in colorectal cancer xenograft tumors. Note the significant effect of [¹⁷⁷Lu]Lu−iFAP/iPSMA on the decrease of tumor cell proliferation with regard to the control group. * Statistically significant difference (p < 0.05).