Dox |
Doxorubicin |
CVDs |
Cardiovascular diseases |
MI |
Myocardial infarction |
DAMPs |
Damage-associated molecular patterns |
PRRs |
Pattern-recognition receptors |
TLRs |
Toll-like receptors |
NOD |
Nucleotide-binding and oligomerization domain |
IL-1 |
Interleukin-1 |
TNFα |
Tumor necrosis factor α |
G-CSF |
Granulocyte colony-stimulating factor |
ECM |
Extracellular matrix |
HMGB1 |
High-mobility group box protein 1 |
IRAK |
IL-1 receptor-associated kinase |
TRAF |
TNF-receptor-associated factor |
TAK |
Transforming growth factor β-activated kinase |
IKK Complex |
IκB complex |
TBK1 |
TANK Binding Kinase-1 |
IRF3 |
Interferon-regulatory factor-3 |
TRIF |
TIR-domain-containing adapter-inducing interferon-β |
NLRP3 |
NOD-, LRR- and pyrin-domain-containing protein 3 |
ASC |
Apoptosis-associated speck-like protein containing a CARD |
MMPs |
Matrix metalloproteinases |
ICAM-1 |
Intercellular adhesion molecule |
VCAM-1 |
Vascular cell adhesion molecule |
TIMP |
Tissue inhibitor of metalloproteinases |
TGFβ |
Tumor growth factor-β |
CXCL1 |
C-X-C Motif Chemokine Ligand 1 |
MCP-1 |
Monocyte chemoattractant protein-1 |
CCL2 |
C-C motif ligand 2 |
CCR2 |
C-C motif receptor 2 |
CXCR4 |
C-X-C Motif chemokine receptor 4 |
ROS |
Reactive oxygen species |
NE |
Neutrophil elastase |
PI3K/AKT |
Phosphatidylinositol 3-kinase/protein kinase B |
ERK |
Extracellular signal-regulated kinases |
JNK |
c-Jun N-terminal kinases |
MAPK |
Mitogen-activated protein kinases |
MHC |
Major histocompatibility complex |
HSPs |
Heat-shock proteins |
ATP |
Adenosine triphosphate |
PAMPs |
Pathogen-associated molecular patterns |
PDGFs |
Platelet-derived growth factors |
IGF-1 |
Insulin-like growth factors-1 |
VEGF |
Vascular endothelial growth factor-1 |
DR4 and 5 |
Death receptors 4 and 5 |
AMPK |
AMP-activated protein kinase |
MIF |
Macrophage migration inhibitory factor |
NT-proBNP |
NT-proB-type Natriuretic peptide |
NOX2 |
NADPH oxidase 2 |
WT |
Wild type |
TUNEL |
Terminal deoxynucleotidyl transferase dUTP nick end labeling |
CX3CR1 |
C-X3-C Motif Chemokine Receptor 1 |
iNKT |
Invariant natural killer T-cells |
αGC |
Alpha-galactosylceramide |