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. 2022 Dec 1;23(23):15109. doi: 10.3390/ijms232315109

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Potential application of natural products in the treatment of NAFLD and LF by modulating autophagy. (A) Natural products alleviated NAFLD by promoting clearance of over-accumulated LDs in an autophagy-dependent manner. VFE, ethanol extract of Valeriana fauriei; CPE, ethanol extract of Cyclocarya paliurus; RPS, the water extract of red peppers seed; CAT, catalpol; EGCG, Epigallocatech in-3-gallate; HK, honokiol; LEP, α-linolenic acid-enriched cold-pressed perilla oil; IA, isopropylidenyl anemosapogenin. (B) On the one hand, natural products decreased the deposition of excessive extracellular matrix by inducing autophagy. On the other hand, some comprised over-activated autophagy in LF to damage fibrosis progression. BA, betulinic acid; PD, Platycodin D; DHI, dihydrotanshinone I; SSd, saikosaponin-d.