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. 2022 Dec 1;27(23):8415. doi: 10.3390/molecules27238415

Figure 6.

Figure 6

(A) Plot showing the StarDrop V7 (Optibrium, Ltd., Cambridge, UK)–derived logS versus a multimetric oral non-CNS profile score. Importance for the score: logS = 0.9, HIA = 0.85, logP = 0.6, logD = 0.6, hERG pIC50 = 0.4, 2D6 affinity category = 0.3, 2C9 pKi = 0.3, P-gp category = 0.3, PPB90 category = 0.2, BBB category = 0.11, BBB log(brain:blood) = 0.11 (B) P-gp category, (C) PPB90 = Plasma protein binding > 90%, (D) HIA = human intestinal absorption category, and probability of prediction of 7f, F2-7f and PF74. The size of the circle correlates with the corresponding score or probability.