[18F]-FDG	18-fluorodeoxyglucose
ABCB1	ATP-binding cassette subfamily B member 1
AD	Alzheimer’s disease
AMPA	α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
ApoE	apolipoprotein E
APP	amyloid precursor protein
ASF	alternative splicing factor
Aβ	amyloid beta peptide
BACE-1	β-site APP-cleaving enzyme 1
BBB	blood-brain barrier
BDNF	brain-derived neurotrophic factor
CNS	central nervous system
CSF	cerebrospinal fluid
DPP4	dipeptidyl peptidase 4
DS	Down syndrome
DYRK1A	dual-specificity tyrosine phosphorylation-regulated kinase 1A
GABA	gamma-aminobutyric acid
GAPDH	glyceraldehyde-3-phosphate dehydrogenase
GLP-1	glucagon-like peptide-1
GLUT	glucose transporter
GSK3β	glycogen synthase kinase 3β
HFD	high-fat diet
i.c.v	intracerebroventricular
IAPP	islet amyloid polypeptide
IDE	insulin-degrading enzyme
IDF	International Diabetes Federation
IGF	insulin-like growth factor
IRS	insulin receptor substrate
ISF	interstitial fluid
JNK	c-Jun N-terminal kinase
LRP1	low-density lipoprotein receptor-related protein 1
NFTs	neurofibrillary tangles
NMDA	N-methyl-D-aspartate
PET	positron emission tomography
PHF	paired helical filaments
PP2A	protein phosphatase 2A
PPAR	peroxisome proliferator-activated receptor
PSD95	postsynaptic density protein 95
PSEN1	presenilin 1
PSEN2	presenilin 2
ROS	reactive oxygen species
sAPPα	soluble APPα fragment
T2D	type 2 diabetes
Tau	tubulin-associated unit
Thr	threonin
TNF-α	tumor necrosis factor alpha
TrkB	tropomyosin receptor kinase B
WHO	World Health Organization