Figure 3.

Key effects of CLL therapeutics on NK function. Current CLL therapeutics have been demonstrated to affect natural killer cells in a variety of ways. This includes directly increasing or decreasing NK cytotoxic function, proliferation, and death. It also includes indirect methods via these therapeutics’ effects on CLL and other cells in the microenvironment. Changes are listed as increases (↑) or decreases (↓), and are color-coded according to whether the measured change is expected to increase (green) or decrease (red) anti-leukemia NK activity.