Table 2.

Cox analyses of prognostic factors in the TCGA cohort.

	Univariate Analysis		Multivariate Analysis
	HR (95%CI)	p Value	HR (95%CI)	p Value
Age
<70	Ref.		Ref.
≥70	1.702 (1.195, 2.424)	<0.001	1.798 (1.259, 2.567)	0.001
Gender
female	Ref.
male	1.058 (0.703, 1.591)	0.788
pT stage
pT1–2	Ref.		Ref.
pT3–4	1.938 (1.258, 2.985)	0.003	1.111 (0.526, 2.345)	0.783
pN stage
pN0–1	Ref.		Ref.
pN2–3	1.907 (1.323, 2.749)	<0.001	1.557 (1.014, 2.391)	0.043
pM stage
pM0	Ref.
pM1	1.849 (0.859, 3.981)	0.116
pTNM stage
Stage II	Ref.		Ref.
Stage III–IV	2.438 (1.591, 3.876)	<0.001	1.407 (0.581, 3.403)	0.449
Lymphovascular invasion
No	Ref.		Ref.
Yes	1.603 (1.128, 2.277)	0.008	1.360 (0.924, 2.003)	0.119
eTILs
Low eTILs	Ref.		Ref.
High eTILs	0.333 (0.199, 0.558)	<0.001	0.345 (0.203, 0.586)	<0.001

95% CI, 95% Confidence Interval; HR, Hazard Ratio.