Table 2.
Univariable logistic regression models for genotype and allele frequencies of the polymorphisms in the study population, according to the presence of thoracic aortic aneurysm.
| Polymorphism | Total (nN = 366) † |
Controls (N = 297) |
TAA (N = 69) |
OR (95% CI) | p-Value |
|---|---|---|---|---|---|
| CTGF_rs6918698 | |||||
| CC | 100 (27.3) | 85 (28.6) | 15 (21.7) | - | |
| CG | 172 (47.0) | 135 (45.5) | 37 (53.6) | 1.55 (0.82–3.08) | 0.190 |
| GG | 94 (25.7) | 77 (25.9) | 17 (24.6) | 1.25 (0.58–2.70) | 0.563 |
| C allele | 372 (50.8) | 305 (51.3) | 67 (48.6) | - | |
| G allele | 360 (49.2) | 289 (48.7) | 71 (51.4) | 1.12 (0.77–1.62) | 0.554 |
| CTGF_rs9402373 | |||||
| CC | 244 (66.7) | 202 (68.9) | 42 (62.7) | - | |
| CG | 104 (28.4) | 80 (27.3) | 24 (35.8) | 1.44 (0.81–2.52) | 0.203 |
| GG | 12 (3.3) | 11 (3.8) | 1 (1.5) | 0.437 (0.02–2.34) | 0.434 |
| C allele | 592 (82.2) | 484 (82.6) | 108 (80.6) | - | |
| G allele | 128 (17.8) | 102 (17.4) | 26 (19.4) | 1.14 (0.70–1.82) | 0.586 |
| CTGF_rs12526196 | |||||
| TT | 303 (82.8) | 250 (85.3) | 53 (79.1) | - | |
| TC | 53 (14.5) | 41 (14.0) | 12 (17.9) | 1.38 (0.66–2.74) | 0.372 |
| CC | 4 (1.1) | 2 (0.7) | 2 (3.0) | 4.72 (0.56–40.03) | 0.125 |
| T allele | 659 (91.5) | 541 (92.3) | 118 (88.1) | - | |
| C allele | 61 (8.5) | 45 (7.7) | 16 (11.9) | 1.63 (0.87–2.93) | 0.113 |
Variables are shown as frequency (%). † n = 360 for CTGF_rs9402373 and CTGF_rs12526196 due to missing genotyping. TAA: thoracic aortic aneurysm; OR: Odds ratio; CI: Confidence interval; OR (95% CI) and p-value for the comparison between Control and TAA groups. -: Reference.