Skip to main content
. 2022 Dec 1;11(23):7154. doi: 10.3390/jcm11237154

Figure 2.

Figure 2

Elemental pathways associated with ASD diagnosis: (A) For each of 210 features measured in each elemental pathway, we constructed a discrete generalized linear model to test for associations with odds of diagnosis with ASD. Models were adjusted for age and sex, and p-values associated with diagnostic status were adjusted via false discovery rates (FDRs). x-axis plots the standardized effect estimate for the effect of ASD diagnosis; dots and corresponding lines reflect the effect estimate and associated 95% confidence interval for each feature. (B) Receiver operating characteristic [38] curve generated from predicting case status in the validation set (n = 97; 28 ASD). (C) Comparison of overall model performance with sex-stratified estimates of model performance. p-values reflect comparison of sex-stratified ROC curves relative to ROC curves in the overall model. (D) Comparison of overall model performance with age-stratified estimates of model performance. p-values reflect comparison of age-stratified ROC curves relative to ROC curves derived in the overall model.