Table 6.
Univariate and multivariate analysis for prognostic factors for disease-free survival.
| Univariable Analysis | Multivariate Analysis | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Before NT | After NT | |||||||||
| Variables | GLIM-Malnutrition | GLIM-Malnutrition + Low VAT | GLIM-Malnutrition | GLIM-Malnutrition + Low VAT | ||||||
| HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Age (≥65) | 1.132 (0.693–1.850) | 0.62 | ||||||||
| Sex (female) | 1.298 (0.777–2.168) | 0.319 | ||||||||
| CCI (≥3) | 0.955 (0.576–1.585) | 0.859 | ||||||||
| NT regimen (NCRT) | 1.197 (0.675–2.122) | 0.538 | ||||||||
| ypstage (III/0-II) | 6.249 (3.846–10.152) | <0.001 | 5.394 (3.281–8.868) | <0.001 | 5.647 (3.452–9.239) | <0.001 | 5.394 (3.245–8.967) | <0.001 | 5.481 (3.309–9.081) | <0.001 |
| Pathologic response (CAP 3/0-2) | 2.335 (1.454–3.752) | <0.001 | ||||||||
| Before NT | ||||||||||
| BMI (≥23) | 0.638 (0.398–1.024) | 0.063 | ||||||||
| NLR (>3) | 2.140 (1.296–3.532) | 0.003 | ||||||||
| Serum PA (<200) | 1.486 (0.895–2.465) | 0.126 | ||||||||
| GLIM-malnutrition | 2.749 (1.709–4.423) | <0.001 | 2.038 (1.252–3.319) | 0.004 | ||||||
| GLIM-malnutrition + low VAT | 2.823 (1.757–4.536) | <0.001 | 2.312 (1.429–3.741) | 0.001 | ||||||
| After NT | ||||||||||
| BMI (≥23) | 0.890 (0.554–1.431) | 0.631 | ||||||||
| NLR (>3) | 1.206 (0.670–2.170) | 0.532 | ||||||||
| Serum PA (<200) | 2.195 (1.336–3.607) | 0.002 | ||||||||
| GLIM-malnutrition | 2.587 (1.609–4.159) | <0.001 | 1.662 (1.009–2.736) | 0.046 | ||||||
| GLIM-malnutrition + low VAT | 2.695 (1.637–4.437) | <0.001 | 1.701 (1.012–2.859) | 0.045 | ||||||
Abbreviations: NT, neoadjuvant treatment; GLIM, the Global Leadership Initiative on Malnutrition; VAT, visceral adipose tissue; CCI, Charlson comorbidity index; NCRT, neoadjuvant chemoradiotherapy; ypstage, post-neoadjuvant therapy stage; CAP, tumor regression grading of College of American Pathologists; BMI, body mass index; NLR, Neutrophil-lymphocyte ratio; Serum PA, Serum prealbumin; HR, hazard ratio; CI, confidence interval. Note: One of the malnutrition diagnoses (GLIM-malnutrition or GLIM-malnutrition + low VAT) was incorporated into Multivariate analysis. - The bold values represent statistical significance, p < 0.05.