Table 1.
Pharmacokinetic parameters of M10 in DSS-group mice and normal-group mice after oral administration of M10 at a dose of 50 mg/kg (mean ± SD, n = 3).
| Pharmacokinetic Parameters | DSS Group | Normal Group |
|---|---|---|
| Cmax (ng/mL) | 174.40 ± 55.99 | 115.07 ± 37.14 |
| Tmax (h) | 0.50 ± 0.43 | 0.28 ± 0.21 |
| T1/2 (h) | 1.05 ± 0.86 | 1.77 ± 0.49 |
| AUC0–t (ug/L * h) | 142.87 ± 83.81 | 170.50 ± 15.10 |
| AUC0–∞ (ug/L * h) | 215.81 ± 180.59 | 213.98 ± 22.43 |
| V (L/kg) | 142.16 ± 17.18 ** | 354.79 ± 78.15 |
| CL (L/h/kg) | 136.30 ± 79.38 | 62.57 ± 34.56 |
| MRT (h) | 0.81 ± 0.27 ** | 1.94 ± 0.27 |
** p < 0.01 for DSS-group mice compared with normal-group mice.