Table 2.
Pharmacokinetic parameters of M10 in DSS-group mice tissues after oral administration of M10 at a dose of 50 mg/kg (mean ± SD, n = 3).
| Parameters | Colon | Small Intestine | Stomach | Liver | Spleen | Lung | Kidney |
|---|---|---|---|---|---|---|---|
| Cmax (ng/mL) | 5742.32 ± 3986.73 | 8332.84 ± 3882.24 | 156,014.34 ± 74,478.59 | 417.13 ± 91.93 | 242.35 ± 34.51 | 133.65 ± 41.13 | 5607.33 ± 1791.25 |
| Tmax (h) | 2.03 ± 1.96 | 0.08 ± 0.00 | 0.08 ± 0 | 2.25 ± 3.25 | 2.67 ± 1.56 | 0.5 ± 0.43 | 2.06 ± 3.42 |
| T1/2 (h) | 0.52 ± 0.53 | 7.20 ± 7.34 | 2.06 ± 0.70 | 28.14 ± 0 | 7.15 ± 2.17 | 1.13 ± 0.80 * | 2.75 ± 2.05 |
| MRT (h) | 0.524 ± 0.53 * | 1.45 ± 0.35 | 1.26 ± 0.25 | 4.20 ± 0.45 | 3.97 ± 0.20 | 1.88 ± 0.70 | 3.73 ± 1.73 |
| AUC0–t (ug/L * h) | 6694.89 ± 7279.721 | 4248.33 ± 1659.42 | 79,911.87 ± 14,176.32 | 1099.64 ± 212.87 | 1470.70 ± 194.90 | 210.52 ± 35.58 | 5066.59 ± 3652.48 |
| AUC0–∞ (ug/L * h) | 6809.75 ± 7478.41 | 4989.31 ± 1007.26 | 83,897.97 ± 16,033.17 | 2163.86 ± 1645.71 | 2957.86 ± 594.32 | 233.66 ± 48.96 | 10,496.80 ± 11,408.11 |
* p < 0.05 for DSS-group mice compared with normal-group mice.