Table 3.
Pharmacokinetic parameters of M10 in normal-group mouse tissues after oral administration of M10 at a dose of 50 mg/kg (mean ± SD, n = 3).
| Parameters | Colon | Small Intestine | Stomach | Liver | Spleen | Lung | Kidney |
|---|---|---|---|---|---|---|---|
| Cmax (ng/mL) | 1151.71 ± 866.95 | 7552.80 ± 7298.53 | 157,843.55 ± 93,019.05 | 255.77 ± 129.70 | 337.78 ± 154.48 | 107.61 ± 48.38 | 1815.93 ± 2739.13 |
| Tmax (h) | 0.28 ± 0.21 | 0.08 ± 0.00 | 0.39 ± 0.529 | 0.86 ± 1.01 | 1.08 ± 0.88 | 0.75 ± 0.43 | 0.44 ± 0.49 |
| T1/2 (h) | 0.30 ± 0.03 | 5.49 ± 1.39 | 1.01 ± 0.49 | 6.56 ± 4.79 | 7.26 ± 5.85 | 5.77 ± 2.12 | 8.48 ± 3.42 |
| MRT (h) | 1.57 ± 0.35 | 1.81 ± 0.65 | 1.45 ± 0.66 | 3.35 ± 0.39 | 3.76 ± 0.34 | 2.90 ± 0.98 | 2.97 ± 1.27 |
| AUC0–t (ug/L * h) | 1363.56 ± 1297.57 | 3671.18 ± 1222.51 | 112,062.27 ± 30,214.89 | 801.47 ± 52.49 | 1489.83 ± 284.93 | 271.01 ± 44.61 | 2190.79 ± 2018.52 |
| AUC0–∞ (ug/L * h) | 1363.56 ± 1297.57 | 4183.90 ± 1192.63 | 112,300.22 ± 3399.32 | 1540.72 ± 814.39 | 5944.71 ± 5349.06 | 512.52 ± 303.74 | 3414.11 ± 1398.69 |