Table 5.
Tissue–plasma partition coefficients (Kp) of M10 after oral administration of M10 at a dose of 50 mg/kg in the normal and DSS groups (mean ± SD, n = 3).
Group | Colon | Small Intestine | Stomach | Liver | Kidney | Spleen | Lung |
---|---|---|---|---|---|---|---|
DSS group | 57.07 ± 64.86 | 31.89 ± 5.98 | 693.39 ± 343.94 | 9.29 ± 4.94 | 42.41 ± 34.06 | 12.92 ± 6.74 | 1.91 ± 1.25 |
Normal group | 7.90 ± 7.06 | 22.07 ± 9.47 | 665.54 ± 210.34 | 4.71 ± 0.16 | 13.66 ± 13.74 | 8.72 ± 1.30 | 1.61 ± 0.43 |