Figure 2.

The zQ175^Δneo mice display a significantly reduced weight gain in the first weeks compared to WT littermates. Later on, increasing weight loss is appreciable. (A,B) The body weight of male (A) and female (B) WT (○) and zQ175^Δneo mice (●) was measured weekly from 15 to 57 weeks of age. Data are presented as mean ± standard deviation (SD); N = 6. Significance was calculated using multiple unpaired t-tests followed by Holm-Šídák correction and is indicated as ns: not significant, *: p ≤ 0.05, and **: p ≤ 0.01. (C–F) Representative images showing a direct comparison of 15-week-old (C,E) and 57-week-old (D,B) male (C,D) and female (E,F) WT (left) and zQ175^Δneo (right) mice.