Figure 12.

Relationships of expressions and copy number alteration (CNA) effects of PER (period) and CRY (cryptochrome) family members with immune infiltration-related cells, including B cells, cluster of differentiation 4-positive (CD4⁺) T cells, CD8+ T cells, macrophages, neutrophils, and dendritic cells (using TIMER). (A) Correlations of immune infiltration-related cells and expressions of PER1, PER2, PER3, CRY1, and CRY2. (B) CNAs of different circadian factors affect infiltration levels in LUAD. * p<0.05, ** p<0.01, and *** p<0.001, compared to arm-level deletions, the diploid/normal group, and arm-level gain.