Figure 1.

Proposed cell-based treatment of type 1 diabetes. The proposed approach should combine an early diagnosis of T1D, through CEUS (Contrast-Enhanced Ultrasonography) with the proper quantity of Procr+cell progenitors, combined with endothelial cells, derived from IPSCs. This in order to generate and expand islet organoids, that can be then grafted in patients undergoing an immune-regolatory therapy. The latter is required to guarantee a long-term maintenance of the transplanted pancreatic islets.