Figure 6.

Schematic diagram of the mechanisms underlying resveratrol’s effect on induced RA-ILD. After tissue injury, hypoxia-related proteins change in the hypoxic microenvironment, making BNIP3 competitively bind BCL2 and release BCL2-bound BECN1, thus inducing autophagy. After autophagy is initiated, autophagosomes are formed, but the fusion with lysosomes to form autophagosomes is hindered. The effect of resveratrol is mainly in the fusion process of autophagosome and lysosome, to relieve the inhibition state and improve fibrosis.