Table 1.
Physicochemical properties comparison among published PROTACs.
| PROTAC-DB Average (as per 28 October 2022) | ||||||
|---|---|---|---|---|---|---|
| Recruited E3 | MW | logP | nHA | nHD | tPSA | nROB |
| CRBN (3530) | 881.49 | 4.93 | 13.61 | 3.11 | 222.70 | 17.61 |
| VHL (1578) | 1060.34 | 5.89 | 17.35 | 4.77 | 257.70 | 22.69 |
| MDM2 (56) | 1278.78 | 7.20 | 13.37 | 1.47 | 219.20 | 24.61 |
| cIAP1 (95) | 1004.98 | 5.60 | 16.00 | 4.70 | 238.12 | 24.65 |
Molecular weight (MW), partition coefficient (logP), number of hydrogen acceptors (nHA) and donors (nHD), total polar surface area (tPSA) and number of rotatable bonds (nROB) are listed.