Table 3.
Comparison of properties between the most commonly used recruiters.
| Thalidomide | VH032 | Nutlin 3a | LCL161 | |
|---|---|---|---|---|
| E3 Ligase | CRBN | VHL | MDM2 | IAP |
| MW | 258 | 431 | 582 | 499 |
| cLogP | 0.6 | 2 | 5.46 | 3 |
| HBD | 1 | 3 | 1 | 3 |
| HBA | 4 | 5 | 8 | 6 |
| nROB | 1 | 8 | 6 | 10 |
| tPSA | 84 | 108 | 83 | 111 |
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