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. 2022 Dec 6;11(23):3942. doi: 10.3390/cells11233942

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Enrichment analysis of differentially expressed genes (DEGs) in cells containing E616 and E716 oncoproteins. Dot plots of the 20 biological functions or pathways more significantly related with the DEGs modulated by E616 and E716 are depicted. Enrichment analysis was performed using data from GO for (A) E6- and (B) E7-expressing cells; while KEGG analysis exhibited cellular pathways affected in (C) E6- and (D) E7-containing cells. Reactome analysis showed processes associated with (E) E6 and (F) E7 expression. Significantly deregulated processes (p-adj < 0.05) were depicted in red color. Count means the number of genes assigned to a term. GeneRatio refers to the number of observed genes (DEGs) divided by the number of expected genes related to each category.