TABLE 3.
CDC trial: antibody responses in A. nancymai immunized with the yP30P2MSP119 FVO vaccine delivered in six non-Freund's adjuvants that are suitable for use in humansa
| Vaccine formulation | Aotus no. | IIFb | Estimated ELISA titerc
|
|
|---|---|---|---|---|
| Pre | Post | |||
| yP30P2MSP119 in: | ||||
| Alum | AI1624 | 103 | 156 | 256 |
| AI2125 | 10 | 550 | 662 | |
| AI2144 | 102 | 258 | 826 | |
| SBAS2 | AI2138 | 105 | 3,918 | 16,780 |
| AI2153 | 104 | 1,658 | 4,678 | |
| AI0983 | 103 | 2,407 | 2,137 | |
| Lipid A/liposomes | AI1026 | 103 | 145 | 1,555 |
| AI1052 | 104 | 579 | 5,504 | |
| AI2128 | 105 | 606 | 6,056 | |
| Polyphazine | AI0981 | 103 | 422 | 881 |
| AI1615 | 104 | 647 | 742 | |
| AI2136 | 105 | 1,000 | 3,440 | |
| Microspheres | AI0932 | 103 | 6,439 | ND |
| AI1567 | 105 | 584 | 3,926 | |
| Montanide ISA 720 | AI1599 | 103 | 1,319 | 2,339 |
| AI2139 | 105 | 1,044 | 2,000 | |
| AI2143 | 103 | |||
| Saline control | AI1112 | <10 | 23 | 38 |
| AI1113 | <10 | 28 | 36 | |
| AI2009 | <10 | 46 | 58 | |
a
Following P. falciparum (FVO) challenge, all monkeys in this trial reached a parasitemia of more than 5% and required treatment.
b
Reaction against the FVO strain of P. falciparum. Sera were taken on the day of parasite challenge.
c
Determined at A410 of 0.5 using yMSP119 QKNG as capture antigen. Pre, sera taken on the day of parasite challenge; Post, sera taken 4 weeks after the parasite challenge; ND, not determined.