Figure 1.

miRNA profiling in cHF patients and reference subjects. (a) miRNA profiling as a dot plot in a Cartesian graph. x-axis represents log₂ (fold-change) and y-axis represents log₁₀ (median concentration p-value). miRNAs with 1.3-fold changes in concentration level (greater than 0.38 [log₂ (1.3)] and less than 0.38 [log₂ (1/1.3)]) and significant p-value are shown in solid black dots. miRNAs with 1.3-fold changes in concentration level (greater than 0.38 [log₂ (1.3)] and less than 0.38 [log₂ (1/1.3)]) but non-significant p-value are shown in solid grey dots. miRNAs with less than 1.3-fold changes in concentration level (lower than 0.38 [log₂ (1.3)] and higher than 0.38 [log₂ (1/1.3)]) and non-significant p-value are shown in black circles. (b) Bar graph indicating changes in the expression of miRNAs between patients and reference subjects. (c) Schematic workflow for miRNA selection. AUC: area under the curve; cHF: chronic heart failure; FC: fold-change; Q1: first (lowest) quartile; RS: reference subjects; ROC: receiver operating characteristic curve.