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. 2022 Dec 3;23(23):15226. doi: 10.3390/ijms232315226

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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miRNA clustering and enrichment analysis. (a) PPI network of the circulating miRNA signature in cHF. Only interactions with a confidence score higher than 0.8 were considered. Node colours represent targeting miRNA. Grey nodes correspond to STRING-added nodes. (b) Community clusters identified within the main connected component of the PPI network. Clusters with less than 5 genes were excluded. (c) Table with number of target genes regulated by each miRNA, per cluster. cHF: chronic heart failure; PPI: protein-protein interaction.