Table 2.
ROC curve analysis of miRNAs according to their cluster formation.
| AUC ± SD (95% CI) | p-Value | Sensitivity | Specificity | |
|---|---|---|---|---|
| (a) Differentiation of Ejection Fraction | ||||
| Clusters 1–4 miRNAs * | 0.725 ± 0.102 (0.526–0.925) | 0.047 | 0.769 | 0.643 |
| Cluster 5 and 7 miRNAs: miR-107 + miR-139-5p + miR-150-5p |
0.782 ± 0.083 (0.618–0.945) | 0.007 | 0.722 | 0.714 |
| Cluster 6 miRNAs: miR-107 + miR-139-5p + let-7a-5p |
0.582 ± 0.112 (0.363–0.802) | 0.467 | 0.571 | 0.538 |
| Cluster 8 miRNAs: miR-107 + miR-139-5p + miR-342-3p |
0.690 ± 0.097 (0.500–0.881) | 0.068 | 0.611 | 0.643 |
| (b) Differentiation of Underlying Aetiology | ||||
| Cluster 1–4 miRNAs * | 0.789 ± 0.088 (0.617–0.962) | 0.019 | 0.737 | 0.750 |
| Cluster 5 and 7 miRNAs: miR-107 + miR-139-5p + miR-150-5p |
0.643 ± 0.l18 (0.410–0.875) | 0.216 | 0.696 | 0.667 |
| Cluster 6 miRNAs: miR-107 + miR-139-5p + let-7a-5p |
0.691 ± 0.126 (0.443–0.939) | 0.124 | 0.684 | 0.625 |
| Cluster 8 miRNAs: miR-107 + miR-139-5p + miR-342-3p |
0.645 ± 0.106 (0.438–0.853) | 0.193 | 0.636 | 0.500 |
| (c) Differentiation of Need for Rehospitalisation | ||||
| Clusters 1–4 miRNAs * | 0.518 ± 0.118 (0.287–0.749) | 0.880 | 0.471 | 0.600 |
| Cluster 5 and 7 miRNAs: miR-107 + miR-139-5p + miR-150-5p |
0.695 ± 0.092 (0.514–0.877) | 0.080 | 0.636 | 0.600 |
| Cluster 6 miRNAs: miR-107 + miR-139-5p + let-7a-5p |
0.641 ± 0.107 (0.432–0.850) | 0.228 | 0.588 | 0.600 |
| Cluster 8 miRNAs: miR-107 + miR-139-5p + miR-342-3p |
0.700 ± 0.093 (0.518–0.882) | 0.074 | 0.591 | 0.600 |
* Includes all miRNAs: let-7a-5p, miR-107, miR-125a-5p, miR-139-5p, miR-150-5p, miR-30b-5p and miR-342-3p. Numbers in bold indicate statistical significance. (a) Ejection fraction: HFrEF (LVEF < 40; n = 24) and HFpEF (LVEF ≥ 50; n = 22); (b) Background aetiology: ischaemic (n = 14) and non-ischaemic (n = 32); (c) Need for rehospitalisation: rehospitalised (n = 32) and non-rehospitalised (n = 14). AUC: area under the curve; CI: confidence interval; HFpEF: heart failure with preserved ejection fraction; HFrEF: heart failure with reduced ejection fraction; LVEF: left ventricular ejection fraction; ROC: receiver operating characteristic; SD: standard deviation.