Table 3.
Neuroproteome changes in 8-month-aged SAMR1.
| Protein | T8 (SAMR1) | FV |
|---|---|---|
| STMN1 1 | up-regulated | 1.7 ± 0.01 |
| FABPH 1 | up-regulated | 0.8 ± 0.18 |
| IPYR 2 | up-regulated | 2.01 ± 0.2 |
| EFHD2 2 | up-regulated | 1.3 ± 0.05 |
| CALB1 2 | up-regulated | 0.7 ± 0.4 |
| PP1R7 (MW: 33,971 Da) 2 | up-regulated | 0.9 ± 0.1 |
| PP1R7 (MW: 34,021 Da) 2 | up-regulated | 0.4 ± 0.2 |
| MDHC 2 | up-regulated | 2.1 ± 0.21 |
| DOPD 2 | up-regulated | 0.8 ± 0.03 |
| MFA3L 5 | up-regulated | 1.1 ± 0.16 |
| ANXA5 6 | up-regulated | 0.26 ± 0.8 |
| SODC 6 | up-regulated | 0.8 ± 0.14 |
| RSSA 4 | up-regulated | 1.9 ±0.02 |
| SNAA 5−7 | up-regulated | 0.95 ± 0.1 |
Gene Ontology (GO) functional classification: 1: Cytoskeleton and cell motility; 2: Metabolism; 3: Protein Biosynthesis; 4: Nucleotide biosynthesis; 5: Signal transduction; 6: Cell response; 7: Trafficking. STMN: Stathmin; FABPH: Fatty acid binding protein heart; IPYR: Inorganic pyrophosphatase; EFHD2: EF-hand domain-containing D2; CALB1: Calbindin OS; PP1R7: Protein phosphatase 1 regulator subunit 7; MDHC: Malate dehydrogenase cytoplasmatic; DOPD: Dopachrome decarboxylase; MFA3L: Microfibrillar-associated protein 3-like; ANXA5: Annexin 5; SODC: Superoxide dismutase; RSSA:40S ribosomal protein SA; SNAA: Alpha-soluble NSF attachment protein. Table reports the FV: fold variation of each protein.