Table 4.
Neuroproteome changes in 8-month-aged SAMP8.
| Protein | T8 (SAMP8) | FV |
|---|---|---|
| CRYM 3 | down-regulated | 0.4 ± 0.2 |
| PDXK 3 | up-regulated | 1.05 ± 0.01 |
| MDHC 2 | up-regulated | 1.2 ± 0.05 |
| PGAM1 2 | down-regulated | 0.13 ± 0.8 |
| VATB2 7 | down-regulated | 1.7 ± 0.05 |
| DUSP3 2,3 | unchanged | --- |
| STMN1 1 | up-regulated | 0.85 ± 0.11 |
| SODC 6 | down-regulated | 0.8 ± 0.03 |
Gene Ontology (GO) functional classification: 1: Cytoskeleton and cell motility; 2: Metabolism; 3: Protein Biosynthesis; 6: Cell response; 7: Trafficking. CRYM: Kemitine reductase mu-crystallin; PDXK: Pyrodoxal kinase; MDHC: Malate dehydrogenase cytoplasmatic; PGAM1: Phosphoglycerate mutase 1; VATB2: V-type proton ATPase subunit B, brain isoform; DUSP: Dual specificity protein phosphatase 3; STMN: Stathmin; SODC: Superoxide dismutase. Table report the FV: fold variation of each protein.