Table A4.
Comparison of frequency of clinical features in the 2 years prior to diagnosis between early (Stages I, II) and late (Stages III, IV) lung cancer.
| All Patients (n = 711) |
Early and Late Stages (n = 623) |
Early Stage (n = 238) |
Late Stage (n = 385) |
p-Value | |
|---|---|---|---|---|---|
| Cough | 573 (80.59%) | 504 (80.90%) | 209 (87.82%) | 295 (76.62%) | 0.0008 |
| Shortness of breath | 515 (72.43%) | 450 (72.23%) | 184 (77.31%) | 266 (69.09%) | 0.0329 |
| Fatigue | 476 (66.95%) | 418 (67.09%) | 161 (67.65%) | 257 (66.75%) | 0.8863 |
| Chest Pain | 403 (56.68%) | 360 (57.78%) | 145 (60.92%) | 215 (55.84%) | 0.2444 |
| Chest crackles or wheeze | 397 (55.84%) | 344 (55.22%) | 148 (62.18%) | 196 (50.91%) | 0.0077 |
| Back pain | 350 (49.23%) | 306 (49.12%) | 125 (52.52%) | 181 (47.01%) | 0.2099 |
| Weight loss | 308 (43.32%) | 269 (43.18%) | 108 (45.38%) | 161 (41.82%) | 0.4305 |
| Bone pain | 270 (37.97%) | 245 (39.33%) | 114 (47.90%) | 131 (34.03%) | 0.0008 |
| Lymphadenopathy | 151 (21.24%) | 133 (21.35%) | 28 (11.76%) | 105 (27.27%) | 0.0000 |
| Hemoptysis | 118 (16.60%) | 97 (15.57%) | 43 (18.07%) | 54 (14.03%) | 0.2157 |
| Finger clubbing | 39 (5.49%) | 33 (5.30%) | 17 (7.14%) | 16 (4.16%) | 0.1518 |
Footnotes: Excludes individuals with stage 0 or unknown stage. Excludes asymptomatic people but includes screen-detected individuals.