Figure 3.
The p.V600E-mutated BRAF has approximately 500-fold greater activity than its wild-type form (B vs. A), resulting in excessive MAPK signaling and abnormal cell growth, survival, and differentiation.
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.