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. 2022 Dec 1;23(23):15133. doi: 10.3390/ijms232315133

Figure 5.

Figure 5

T314A and M896V GoF mutations do not alter KCNT1 pore permeability to Na+. (A). WT KCNT1. (B). T314A KCNT1. (C). M896V KCNT1. The I-V plots were recorded in response to 100 ms voltage ramps from −120 mV to 120 mV in the control bath solution (4 mM K+) and in a solution with 126 mM NaCl replaced with 126 mM KCl. (D). The shifts in the membrane potential caused by replacing NaCl with KCl were calculated using I-V plots similar to those shown in panels (A–C) and plotted against the KCl concentration changes. The solid curves are the fits of GHK equation (Equation (2), Section 4) to the experimental data.