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. 2022 Dec 1;23(23):15133. doi: 10.3390/ijms232315133

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Distribution of the studied mutations on the 3D model of the KCNT1 channel. Mutations analysed in this paper were mapped onto the 3D structure of the chicken KCNT1 homolog, Slo2_2 in the open conformation deposited in the rcsb.org Protein Data Bank (PDB, http://doi.org/10.2210/pdb5U70/pdb, accessed on 3 November 2022) [20,21], with colours corresponding to the functional domains they are located in (see Section 4). The projection of a single KCNT1 subunit shown in panel (B) is obtained by anticlockwise rotation of the projection shown in panel (A) by 90 degrees around the vertical axis.