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. 2022 Dec 5;23(23):15322. doi: 10.3390/ijms232315322

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Delineation of contours showing marked enhancement. (a) Left cranio-caudal full-field digital mammography showing an extended cluster of microcalcifications in the outer quadrants that were highly suspicious for malignancy (in the red box). (b) Cranio-caudal contrast-enhanced mammography showing minimal background parenchymal enhancement and a marked heterogeneous non-mass enhancement at the site of the microcalcifications. (c) Manual segmentation of the contrast-enhanced area for the radiomic analysis. The final histology revealed a ductal carcinoma in situ (DCIS), ER- and PR-positive, HER2-negative, G3, Ki-67 24%.