FIG. 5.

Effects of anti-IL-12 treatment on C. pneumoniae infection-mediated cytokine production. BALB/c mice were treated with anti-IL-12 at 1 mg/mouse 1 day before bacterial inoculation and subsequently every 5 days at 0.5 mg/mouse during the course of the experiment. Mice were sacrificed on various days p.i. Pulmonary cytokine levels were measured as described in Materials and Methods. Open and filled bars represent control MAb- and anti-IL-12-treated animals, respectively. Data (means ± SD) are from one experiment representative of three independent experiments each with determinations from three to five animals.